2 column themes are most widely used particularly in blogging or any content rich site. I personally feel that WordPress 2 Column theme gives your site better look than 3 or 1 column theme. There are many elegant 2 column themes available, here I am sharing a few best of them
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Have a look on 6 Beautiful Two Column WordPress Themes
Integral Design
Passion Duo Theme
Green Tech Theme
Studio Press Theme
Blue Sensation Theme
Blues Theme